Forecast Leaderboard

PROJECT: Forecasting Reproducibility of Preclinical Cancer Studies

SYNOPSIS: Experts and novices gave subject probability forecasts of preclinical cancer replication studies conducted by the Reproducibility Project: Cancer Biology.

Read the paper here.

See the project page here and more background here.

For more information on how to interpret the results and other FAQs, click here.

Experts: Survey 1

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs (Sugahara),
Discovery and preclinical validation of drug indications using compendia of public gene expression data (Sirota),
Melanoma genome sequencing reveals frequent PREX2 mutations (Berger)

Group median: 0.31; 95% C.I. [0.26,0.36]

Experts: Survey 2

BET bromodomain inhibition as a therapeutic strategy to target c-Myc (Delmore),
Inhibition of BET recruitement to chromatin as an effective treatment for MLL-fusion leukaemia (Dawnson),
The CD47-signal regulatory preotein alpha (SIRPa) interaction is a therapeutic target for human solid tumors (Willingham)

Group median: 0.40; 95% C.I. [0.35,0.44]

Novices: Survey 1

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs (Sugahara),
Discovery and preclinical validation of drug indications using compendia of public gene expression data (Sirota),
Melanoma genome sequencing reveals frequent PREX2 mutations (Berger)

Group median: 0.32; 95% C.I. [0.26,0.37]

Do you think you can beat these experts? Write us at forecasting@translationalethics.com or daniel.benjamin2@mail.mcgill.ca to see what other forecasting competitions we are running.

Scores are published with individual forecaster approval.
Contact us at any time if you would like your name removed from our leaderboard.

2017 May 31 | No comments please

@Manual{stream2017-1302,
    title = {Forecast Leaderboard},
    journal = {STREAM research},
    author = {STREAM admin},
    address = {Montreal, Canada},
    date = 2017,
    month = may,
    day = 31,
    url = {https://www.translationalethics.com/forecast-scoreboard/}
}